Fairness in Drug Sentencing Act of 2007 - Amends the Controlled Substances Act and the Controlled Substances Import and Export Act to increase (by a factor of five) the amount of a controlled substance or mixture containing a cocaine base (i.e., crack cocaine) required for the imposition of mandatory minimum prison terms for trafficking in such controlled substance.

Eliminates the five-year mandatory minimum prison term for first-time possession of crack cocaine.

Directs the U.S. Sentencing Commission to review and amend, if appropriate, its sentencing guidelines for trafficking in a controlled substance to reflect the use of a dangerous weapon or violence in such crime and the culpability and role of the defendant in such crime.